Senthilkumar PK

Senthilkumar PK
Program: 
Ph.D.
Year of graduation: 
2012

I joined the Human Toxicology Program at the University of Iowa in 2007

I’ve probably always been interested in Science in one form or another, and in particular I’ve been drawn to Biology. I did my Veterinary Medicine followed up with masters in Pharmacology and Toxicology. As an aspirant of Molecular Toxicology, I have an intriguing desire inside me to comprehend the molecular basics of complex toxicological mechanisms taking place at the cellular level that leads to cancer. An extremely distinguished faculty, a milieu replete with academic activity, and a graduate program which blends high quality course work and research facilities at the cutting edge of every sub-field are the factors which have motivated me to choose The University of Iowa for PhD program in Human Toxicology. I feel that doctoral study at this University will be the most logical extension of my academic pursuits and a major step towards achieving my objectives.

Previous education:

Doctorate in Veterinary Medicine
Tamil Nadu Veterinary and Animal Sciences University, India, 2003
M.V.Sc, Pharmacology and Toxicology
Kerala Agricultural University, India, 2005
Current research description: 

I am interested in studying the role of polychlorinated biphenlys (PCBs) on DNA damage, cell cycle disturbance along with the regulation of telomerase activity in the development of lung cancer.

 

Thesis title: 

Telomerase and telomere dysregulation in polychlorinated biphenyl (PCB) exposed human skin keratinocytes

Publications: 

Senthilkumar, P.K., Flor, S., Robertson, L., and Ludewig, G. (2008) Toxic Effects of Chicago Airborne Polychlorinated Biphenyls and Aroclors - a Comparative Study. Central States Society of Toxicology Annual Meeting. University of Kansas Medical Center, Kansas City, Kansas, USA, 53.

Senthilkumar Perumal Kuppusamy., Yueming Zhu., Nukhet Aykin-Burns., Larry W Robertson., Hans-Joachim Lehmler., and Douglas R Spitz.(2008). Cell growth phase specific PCB-induced alternations in the superoxide levels in human prostate epithelial cells. The Fifth PCB Workshop- New Knowledge Gained From Old Pollutants, Iowa City, Iowa, USA, 82.

SenthilKumar, P.K., Nair, A.M.C. , Ramnath, V., and Vickramachakravarthy, P. (2006). In vivo clastogenic effects of cyclophosphamide and mitomycin-C and its protective action by fraction of Emblica officinalis in mice. International conference on Ethnopharmacology and Alternative Medicine, Amala Cancer Research Institue, Thrissur, India, 59.

Senthilkumar, P.K.; Klingelhutz, A.J.; Jacobus, J.A.; Lehmler, H.; Robertson, L.W.; Ludewig, G. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). TOXICOLOGY LETTERS, JUL 4 2011,204(1): 64-70.

Senthilkumar, P.K.; Robertson, L.W.; Ludewig, G.PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). TOXICOLOGY AND APPLIED PHARMACOLOGY FEB 15 2012, 259(1): 115-123.

Awards and honors: 

Graduate Student Travel Award, University of Iowa, 2009

ECGPS Travel Award, University of Iowa, 2009

Indian Council of Agricultural Research (ICAR) fellowship for pursuing my post graduation in Pharmacology and Toxicology

Current position: 
Toxicologist
Current employer/institution: 
NIOSH