William Klaren

William Klaren
Program: 
Ph.D.
Year of graduation: 
2016

It has recently been shown that hepatic metal homeostasis is altered upon exposure to PCB126 (a potent Ah receptor agonist).  My work focuses on this disruption (in particular copper, zinc and selenium changes) and its potential to cause or abrogate the classical symptoms of highly chlorinated PCB toxicity. 

I joined the toxicology program in the summer of 2011 after rotating with Dr. Larry Robertson as part of the Biosciences Program.  I find toxicology interesting because it tends to be the culmination of a multitude of changes that causes the ultimate toxicity. 

I have lived in Iowa all of my life, attending a small liberal arts college for my undergraduate degree in biochemistry.  I enjoy golfing and being outdoors and I look forward to having fun and partaking in some interesting science.

Previous education:

BS, Biochemistry
Loras College, Dubuque, IA, 2010
Thesis title: 

Assessment of hepatic micronutrients disruption and the hepatotoxicity of 3,3’,4,4’,5-pentachlorobiphenyl (PCB126)

Publications: 

Gadupudi, GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW.  PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicological Science (2015),In Press .PMID: 26396156, PMCID: PMC4731404.

 

William Klaren, Gopi Gadupudi, Brian Wels, Donald Simmons, Alicia Olivier, and Larry W. Robertson. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Toxicology, 2015, 3381-7. PMID: 26419179, PMCID:PMC4658301.

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Lai, I.K., Klaren, W.D., Li, M., Wels, B., Simmons, D.L., Olivier, A.K., Haschekm W.M., Wang, K., Ludewig, G., Robertson, L.W. (2013) Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver? Chemical Research in Toxicology, 26 634−644. PMID: 23527585, PMCID: PMC3660509.

 

Klaren WD, Gibson-Corley K, Wels B, Simmons D, McCormick M, Spitz DR, Robertson LW. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol. 29, 851-859, 2016, PMID:  26967026, PMCID: PMC In Progress

Awards and honors: 

KC Donnelly Award, NIEHS Superfund Program

2014 Society of Toxicology Gradute Student Travel Award

2015 NIEHS Health Sciences Student Poster Award

Current position: 
Post-doc Fellow
Current employer/institution: 
Texas A&M