During my final undergraduate year, I did a year-long research project at the University of Iowa. This project was part of my degree in chemistry. I was guided during this project in part by Dr. Larry Robertson, the director of the human toxicology program.
During this time I became increasingly interested in the field of toxicology. Toxicology was a perfect mix of chemistry, biology and physics. This ultimately lead to the start of my PhD degree in the UI human toxicology program. I was part of Dr. Garry Buettner's lab. Dr. Buettner is director of the ESR facility, which utilizes a technique to detect free radicals. Part of my research involved the use of these machines, as well as using chemical and biological approaches to quantify anti-oxidant protiens in various normal and cancer cells.
Dissertation Title: Discoveries on the Storage of Red Blood Cells and the Exposure of Cells in Culture to Xenobiotics
Advisor: Garry Buettner, Ph.D.
Year of Graduation: 2013
Program: Ph.D.
Current Position: Toxicologist
Current Employer/Institution: Michigan Department of Health & Human Services
Publications from Human Toxicology Research:
Wagner BA, Witmer JR, van 't Erve TJ, Buettner GR., An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells., Redox Biol. 2013;1(1):210-217
Doskey CM, van 't Erve TJ, Wagner BA, Buettner GR., Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture, PLoS One. 2015 Jul 14;10(7):e0132572
Van 't Erve TJ, Wagner BA, Martin SM, Knudson CM, Blendowski R, Keaton M, Holt T, Hess JR, Buettner GR, Ryckman KK, Darbro BW, Murray JC, Raife TJ., The heritability of hemolysis in stored human red blood cells, Transfusion. 2015 Jun;55(6):1178-85
van 't Erve TJ, Doskey CM, Wagner BA, Hess JR, Darbro BW, Ryckman KK, Murray JC, Raife TJ, Buettner GR., Heritability of glutathione and related metabolites in stored red blood cells, Free Radic Biol Med. 2014 Nov;76:107-13.
van 't Erve TJ, Wagner BA, Ryckman KK, Raife TJ, Buettner GR., The concentration of glutathione in human erythrocytes is a heritable trait, Free Radic Biol Med. 2013 Dec;65:742-749.
Olney KE, Du J, van 't Erve TJ, Witmer JR, Sibenaller ZA, Wagner BA, Buettner GR, Cullen JJ., Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity, Free Radic Res. 2013 Mar;47(3):154-63
Ekuase EJ, van 't Erve TJ, Rahaman A, Robertson LW, Duffel MW, Luthe G., Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes., Environ Sci Pollut Res Int. 2016 Feb;23(3):2119-27
van 't Erve TJ, Rautiainen RH, Robertson LW, Luthe G., Trimethylsilyldiazomethane: a safe non-explosive, cost effective and less-toxic reagent for phenol derivatization in GC applications., van 't Erve TJ, Rautiainen RH, Robertson LW, Luthe G.
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