During my undergraduate studies I spent half a year in Sweden where I completed a research project at the Karolinska Institute. At that time I realized that studying abroad is an opportunity I definitely want to take advantage of thus I started looking for universities and programs that fit my research interests and education. The Ph.D. program in Human Toxicology at the University of Iowa fit my interests most because it combines a variety of natural sciences and offers a multitude of research possibilities.
Dissertation Title: Regulatory Crosstalk and Interference between the PCB 126 Stimulated AhR and Hypoxia Stimulated HIF-1α Signaling Pathways full text
Advisor: Frederick E. Domann
Year of Graduation: 2014
Program: Ph.D.
Current Position: Chief Operating Officer
Current Employer/Institution: HepaPredict AB
Publications:
Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. Hypoxia perturbs aryl hycrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Tox Appl Pharm 274 (2014): 408-16.
Place TL, Fitzgerald MP, Venkataraman S, Vorrink SU, Case AJ, Teoh ML, Domann FE,, Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells, PLoS One. 2011 Jan 28;6(1):e14617. doi: 10.1371/journal.pone.0014617.
Hallberg AR, Vorrink SU, Hudachek DR, Cramer-Morales K, Milhem MM, Cornell RA, Domann FE., Aberrant CpG methylation of the TFAP2A gene constitutes a mechanism for loss of TFAP2A expression in human metastatic melanoma, Epigenetics. 2014 Dec;9(12):1641-7. doi: 10.4161/15592294.2014.988062
Vorrink SU, Hudachek DR, Domann FE., Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126), Int. J. Mol. Sci. 2014, 15(8), 13916-13931
Vorrink SU, Sarsour EH, Olivier AK, Robertson LW, Goswami PC, Domann FE., PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells, Exp Toxicol Pathol. 2014 Oct;66(8):377-82
Vorrink SU, Domann FE, Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node, Chem Biol Interact. 2014 Jul 25;218:82-8.
Xiao W, Son J, Vorrink SU, Domann FE, Goswami PC., Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes, Toxicol Lett. 2015 Mar 18;233(3):258-66.
Adamcakova-Dodd A, Stebounova LV, Kim JS, Vorrink SU, Ault AP, O'Shaughnessy PT, Grassian VH, Thorne PS., Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models, Part Fibre Toxicol. 2014 Apr 1;11:15
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