I joined the Human Toxicology Program at the University of Iowa in 2008.

The endless possibility of trying out, and the instant knowledge of the outcome that stimulates an urge for further research, is what I find most appealing about studying toxicology. Having an explorative and inquisitive attitude leads to a constant learning process. After completion of my Masters degree in Zoology and three years of research in toxicology, I look to a PhD to refine my skills and knowledge in the area of toxicology. It will also give a direction to my goal as a research professional at an academic, research oriented or commercial organization.

Thesis Title: The Role of Sirtuin 3 in Regulating Mitochondrial Superoxide Metabolism in Response to Ionizing Radiation in Mouse Embryonic Fibroblasts

Advisor: Douglas Spitz, Ph.D.

Year of Graduation: 2013

Program: Ph.D.

Current Position: Assistant Research Scientist, Radiation Oncology

Current Employer/Institution: The University of Iowa

Publications: 

Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR, 2014, Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3, Antioxid Redox Signal.;20(9):1423-35. PMCID: PMC3936509

Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR, 2013, Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender, Radiat Res;180(2):156-65. PMCID: PMC3821998

Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med. 2012 Jan 15;52(2):436-43. Epub 2011 Nov 4.

LinkedIn Page