Prajwal Gurung, Ph.D.
Campus address: E176 MTF
Primary department: Internal Medicine
Interdisciplinary program(s): Human Toxicology
Research description: Pattern recognition receptors (PRRs) sense pathogen/damage-associated molecular patterns to protect and maintain cellular homeostasis. Nod like receptors (NLRs), a family of cytoplasmic sensors, recognize pathogen/damage-associated molecules within the cell. Several studies including ours have shown that these NLRs play a central role, not only in viral, bacterial and parasitic infections but also in autoinflammatory and autoimmune diseases.
The research goals of our lab are to investigate how these NLRs regulate innate and adaptive immune responses. To unravel the underlying mechanisms governing NLRs and their function, we use bacterial, parasitic and viral infection of mice, as well as autoinflammatory disease models.