Having worked for the Food and Drug Administration, I realized that toxicology is an indispensable field to keep people safe from toxic substances. I chose the Human Toxicology program at the UI to study profound toxicology in order to understand mechanisms and toxicity of environmental toxic compounds to human health.

Dissertation Title: Prostaglandin H Synthase Catalyzes the Oxidation of 4-Chlorobiphenyl Metabolites, and In Vivo Effects on Prostaglandin Production

Advisor: Larry Robertson, Ph.D.

Year of Graduation: 2011

Program: Ph.D.

Current Position: Pharmacist

Current Employer/Institution: Sirindhorn College of Public Health

Publications from Human Toxicology Program Research:

Wangpradit, O., Mariappan, S. V., Teesch, L. M., Duffel, M. W., Norstrom, K., Robertson, L. W., and Luthe, G. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Tox 2009, 22:64-71.

Wangpradit O, Moman E, Nolan KB, Buettner GR, Robertson LW, Luthe G. Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2. Chemosphere. 2010 Dec; 81(11):1501-8.

Wangpradit O, Adamcakova-Dodd A, Heitz K, Robertson L, Thorne PS, Luthe G., PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats, Environ Sci Pollut Res Int. 2016 Feb; 23(3):2128-37. doi: 10.1007/s11356-015-5022-5, PMID: 26400242

Wangpradit O, Rahaman A, Mariappan SV, Buettner GR, Robertson LW, Luthe G., Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids, Environ Sci Pollut Res Int. 2016 Feb;23(3):2138-47. doi: 10.1007/s11356-015-5007-4. PMID: 26396011