Lalita Mazgaeen
I am from the Himalayan country Nepal. I received my B.S. in Biotechnology at SANN International College (Purbanchal University) in Nepal. During my undergraduate I worked on a project that involved using different molecular techniques to detect rare form of diabetes; MODY in Diabetic population of Kathmandu.
I came to US in 2014 and joined the M.S. program at Southern Illinois University, Edwardsville with a focus on Environmental Chemistry and Toxicology. However, my thesis project was on improvement of RNAi technology in Drosophila. I worked with DDT-resistant fruit flies and was very interested to learn about the mechanism how pesticides affect the biological processes.
I joined the Human Toxicology Doctoral program at University of Iowa in Fall 2017. I was attracted to this program as it is interdisciplinary. Human toxicology program seems to be the best fit for me to gain new insight into these processes and broaden the horizon of my research capability.
Dissertation Title: A protective role for CD47 in inhibiting aberrant inflammation and death of Ptpn6spin mice
Advisor: Prajwal Gurung, PhD
Program: Ph.D.
Current Position: Postdoctoral Research Associate in Immunology
Current Employer/Institution: Duke University
Publications from Human Toxicology Program Research:
Lalita Mazgaeen, Prajwal Gurung, Recent advances in lipopolysaccharide recognition systems, Int. J. Mol. Sci. 2020, 21(2), 379
Ju Hyeon Kim; Joseph A Moreau; Jake M Zina; Lalita Mazgaeen; Kyong Sup Yoon; Barry R Pittendrigh; J Marshall Clark, Identification and interaction of multiple genes resulting in DDT resistance in the 91-R strain of Drosophila melanogaster by RNAi approaches, Pesticide Biochemistry and Physiology, Volume 151, October 2018, Pages 90-99
Lalita Mazgaeen Matthew Yorek, Saurabh Saini, Peter Vogel, David K. Meyerholz, Thirumala-Devi Kanneganti, Prajwal Gurung, CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation, Science Advances, 6 Jan 2023, Vol 9, Issue 1
Barun Poudel; Matthew S Yorek ;Lalita Mazgaeen; Scott A Brown; Thirumala-Devi Kanneganti; Prajwal Gurung, Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection, ImmunoHorizons., 2020, Vol.4(9), p.546-560
Yorek, Matthew S; Poudel, Barun; Mazgaeen, Lalita; Pope, R Marshall; Wilson, Mary E; Gurung, Prajwal; Louzir, Hechmi, Leishmania major degrades murine CXCL1 – An immune evasion strategy, PLoS neglected tropical diseases. , 2019, Vol.13(7), p.e0007533
L Mazgaeen, P Gurung, Neutro “feels” lethal toxin, J Leukoc Biol. 2020 Sep; 108(3): 769–772
Matthew S. Yorek, Lalita Mazgaeen, Prajwal Gurung, Leishmania major degrades murine CXCL1, FASB Journal, 20 April 2020
Prajwal Gurung; Matthew Yorek; Barun Poudel; Lalita Mazgaeen, Leishmania major degrades CXCL1 to subvert host immune responses, J Immunol (2019) 202 (1_Supplement): 127.3.
