Kiran Dhakal

Biography

I joined Interdisciplinary graduate program in human toxicology in 2009. After completing three lab rotations, I joined Dr. Robertson’s lab in June 2010. My research area is inhalation toxicity of lower chlorinated PCBs. Taking a prototypical congener (PCB3), I’m looking at different phase II metabolites in urine in order to identify a potential biomarker metabolite for assessment of environmental exposure to lower chlorinated PCBs. Additionally, I’m also looking at genotoxicity, specifically mutation frequency in lungs, following sub-chronic inhalation of PCB3 in a rat model.

Thesis Title: Urinary sulfate conjugates are markers of inhalation exposure to 4-chlorobiphenyl (PCB3)

AdvisorLarry Robertson, Ph.D.

Year of Graduation: 2014

Program: Ph.D.

Current Position: Director

Current Employer/Institution: 2SD Toxicology Services

Publications: Dhakal, K., Adamcakova-Dodd, A., Lehmler, H.J., Thorne, P. S., and Robertson, L.W. Elimination kinetics of PCB3 after  acute inhalation exposure in female rats.  Manuscript in progress. 2013.

Dhakal, K., Adamcakova-Dodd, A., Lehmler, H.J., Thorne, P. S., and Robertson, L.W.  2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chemical Research in Toxicology. 26, 853-855.

Dhakal, K., He, X., Lehmler, H. J., Teesch, L. M., Duffel, M. W., and Robertson, L. W. 2012. Identification of Sulfated Metabolites of 4-Chlorobiphenyl (PCB3) in the Serum and Urine of Male Rats. Chemical Research in Toxicology. 25, 2796-2804.

Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, et al. 2012. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology.

John A Pickrell, Kiran Dhakal and Sharon M. Gwaltney-Brant. Respiratory System Toxicology. “Small animals Toxicology Essentials”.   ISBN: 978-0-8138-1538-1. Wiley-Blackwell publications. 2011.

Dhakal K. and Pickrell J. (2009). Comparative in vitro Estimates of Inhalation Toxicity of Selected Nannoparticles. MPH thesis. Kansas State University. Full text

Kiran Dhakal
BVSc, Bachelor in Veterinary Science, Tribhuvan University Nepal, MPH, Master of Public Health, Kansas State University, Manhattan, KS