Kiran Dhakal
I joined the Interdisciplinary graduate program in human toxicology in 2009. After completing three lab rotations, I joined Dr. Robertson’s lab in June 2010. My research area was inhalation toxicity of lower chlorinated PCBs. Taking a prototypical congener (PCB3), I’m looked at different phase II metabolites in urine in order to identify a potential biomarker metabolite for assessment of environmental exposure to lower chlorinated PCBs. Additionally, I’m also looked at genotoxicity, specifically mutation frequency in lungs, following sub-chronic inhalation of PCB3 in a rat model.
Thesis Title: Urinary sulfate conjugates are markers of inhalation exposure to 4-chlorobiphenyl (PCB3)
Advisor: Larry Robertson, Ph.D.
Year of Graduation: 2014
Program: Ph.D.
Current Position: Director
Current Employer/Institution: 2SD Toxicology Services
Publications:
Dhakal, K., Adamcakova-Dodd, A., Lehmler, H.J., Thorne, P. S., and Robertson, L.W. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chemical Research in Toxicology. 26, 853-855.
Dhakal, K., He, X., Lehmler, H. J., Teesch, L. M., Duffel, M. W., and Robertson, L. W. 2012. Identification of Sulfated Metabolites of 4-Chlorobiphenyl (PCB3) in the Serum and Urine of Male Rats. Chemical Research in Toxicology. 25, 2796-2804.
Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, et al. 2012. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology, Volume 302, Issue 1, 8 December 2012, Pages 25-33
Kiran Dhakal, Gopi S. Gadupudi, Hans-Joachim Lehmler, Gabriele Ludewig, Michael W. Duffel & Larry W. Robertson, Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs), Environmental Science and Pollution Research volume 25, pages 16277–16290 (2018)
