I joined Interdisciplinary graduate program in human toxicology in 2009. After completing three lab rotations, I joined Dr. Robertson’s lab in June 2010. My research area is inhalation toxicity of lower chlorinated PCBs. Taking a prototypical congener (PCB3), I’m looking at different phase II metabolites in urine in order to identify a potential biomarker metabolite for assessment of environmental exposure to lower chlorinated PCBs. Additionally, I’m also looking at genotoxicity, specifically mutation frequency in lungs, following sub-chronic inhalation of PCB3 in a rat model.
Thesis Title: Urinary sulfate conjugates are markers of inhalation exposure to 4-chlorobiphenyl (PCB3)
Advisor: Larry Robertson, Ph.D.
Year of Graduation: 2014
Current Position: Director
Current Employer/Institution: 2SD Toxicology Services
Publications: Dhakal, K., Adamcakova-Dodd, A., Lehmler, H.J., Thorne, P. S., and Robertson, L.W. Elimination kinetics of PCB3 after acute inhalation exposure in female rats. Manuscript in progress. 2013.
Dhakal, K., Adamcakova-Dodd, A., Lehmler, H.J., Thorne, P. S., and Robertson, L.W. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chemical Research in Toxicology. 26, 853-855.
Dhakal, K., He, X., Lehmler, H. J., Teesch, L. M., Duffel, M. W., and Robertson, L. W. 2012. Identification of Sulfated Metabolites of 4-Chlorobiphenyl (PCB3) in the Serum and Urine of Male Rats. Chemical Research in Toxicology. 25, 2796-2804.
Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, et al. 2012. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology.
John A Pickrell, Kiran Dhakal and Sharon M. Gwaltney-Brant. Respiratory System Toxicology. “Small animals Toxicology Essentials”. ISBN: 978-0-8138-1538-1. Wiley-Blackwell publications. 2011.
Dhakal K. and Pickrell J. (2009). Comparative in vitro Estimates of Inhalation Toxicity of Selected Nannoparticles. MPH thesis. Kansas State University. Full text