During my undergraduate studies I majored in cancer biology and when I was looking for appropriate graduate studies I became most interested in the Ph.D. program in “Human Toxicology” at the University of Iowa. Toxicology is a diverse and highly interdisciplinary scientific field that imparts knowledge from basic natural sciences and medicine and therefore perfectly met my interests.

Dissertation Title: Toxicological and Therapeutic Implications of Interactions Between Polychlorinated Biphenyl Sulfates and Human Transthyretin

Advisor: Michael Duffel, Ph.D.

Year of Graduation: 2014

Program: Ph.D.

Current Position: Head of Toxicology and Ecotoxicology

Current Employer/Institution: Clariant, located in Sulzbach (Germany)

Publications: 

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW. Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin. Environ Health Perspect. (2013) 121: 657-62.

Grimm FA, Lehmler HJ, Koh WX, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW., Identification of a sulfate metabolite of PCB 11 in human serum, Environ Int. 2017 Jan;98:120-128. doi: 10.1016/j.envint.2016.10.023

Grimm FA, He X, Teesch LM, Lehmler HJ, Robertson LW, Duffel MW., Tissue Distribution, Metabolism, and Excretion of 3,3'-Dichloro-4'-sulfooxy-biphenyl in the Rat, Environ Sci Technol. 2015 Jul 7;49(13):8087-95. doi: 10.1021/acs.est.5b01499

Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman Å, Robertson LW, Metabolism and metabolites of polychlorinated biphenyls, Crit Rev Toxicol. 2015 Mar;45(3):245-72. doi: 10.3109/10408444.2014.999365

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW., Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models, Chem Biol Interact. 2015 Feb 25;228:1-8. doi: 10.1016/j.cbi.2015.01.002

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