Tuesday, June 28, 2016

Dr. Hans Joachim Lehmler, Human Toxicology Professor at the University of Iowa, had a paper accepted into the prestigious journal Toxicological Sciences. The paper is entitled " 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats." The hypothesis tested was PCB 126 exposure alters the levels of oxylipins in rats. The results suggest that oxylipins are potential biomarkers of exposure to PCB 126 and that the P450/sEH pathway is a therapeutic target for PCB 126-mediated hepatotoxicity that warrants further attention. 

Dr. Lehmler collaborated on the project with fellow ISRP researcher Dr. Larry Robertson, Post-Doc fellow Xianai Wu, and three researchers from the University of California-Davis: Jun Wang, Christophe Morisseau, and Bruce Hammock.