Jeffrey Stolwijk

Biography

I am from The Netherlands and lived in a city called Enschede, a city near the German border. I received my Bachelor of Applied Sciences in Chemistry in the Life Sciences Faculty at Saxion University of Applied Sciences in Enschede. I had a broad spectrum of classes I had to attend to obtain a multidisciplinary work style.

In my final 2 years of my undergraduate program, I focused on nanotechnology and Nanochemistry and surface chemistry in particular. I am fascinated by functionalities and naostructures made by nature.

Thesis TitleSupplementation of Cell Culture Media with Seleno-L-Methionine Increases the Activity of Glutathionine Peroxidases Resulting in a Reduction of Cellular Lipid Peroxidation

AdvisorGarry Buettner, Ph.D.

Program: Ph.D.

Current PositionCo-Founder & Chief Technology Officer

Current Employer/Institution: Spheres4Life B.V.

Publications from Human Toxicology Program Research:

Jeffrey M Stolwijk, Rohan Garje, Jessica C Sieren , Garry R Buettner , Yousef Zakharia, Understanding the Redox Biology of Selenium in the Search of Targeted Cancer Therapies, Antioxidants (Basel). 2020 May 13;9(5):420

Gibson AR, O'Leary BR, Du J, Sarsour EH, Kalen AL, Wagner BA, Stolwijk JM, Falls-Hubert KC, Alexander MS, Carroll RS, Spitz DR, Buettner GR, Goswami PC, Cullen JJ., Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity, Cancer Res. 2020 Apr 1;80(7):1401-1413.

Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR., Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper, Free Radic Biol Med. 2020 Apr;150:1-11

Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov VE, Stolwijk JM, Lehmler HJ, Hornbuckle KC, Ludewig G, Robertson LW, Thorne PS., Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs, Environ Sci Technol. 2020 Dec 15;54(24):15976-15985

Petronek MS, Stolwijk JM, Murray SD, Steinbach EJ, Zakharia Y, Buettner GR, Spitz DR, Allen BG., Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy, Redox Biol. 2021 Jun;42:101864

Mehdi Z, Petronek MS, Stolwijk JM, Mapuskar KA, Kalen AL, Buettner GR, Cullen JJ, Spitz DR, Buatti JM, Allen BG., Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy., Int J Mol Sci. 2021 Oct 8;22(19):10880

Stolwijk JM, Stefely JA, Veling MT, van 't Erve TJ, Wagner BA, Raife TJ, Buettner GR., Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage, Redox Biol. 2021 Oct;46:102073

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Jeffrey Stolwijk