Elise Fletcher (Higginbotham)
Thesis Title: Epidermal growth factor receptor inhibition induces Interleukin-6 via NADPH oxidase enzymes in head and neck cancer
Advisor: Andrean L. Simons-Burnett, PhD
Year of Graduation: 2012
Current Position: Sales Executive
Current Employer/Institution: Abbott
Publications from Human Toxicology Program Research:
Arya Sobhakumari, Laurie Love-Homan, Elise V M Fletcher, Sean M Martin, Arlene D Parsons, Douglas R Spitz, C Michael Knudson, Andrean L Simons, Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism, PLoS One, 2012;7(10):e48175,doi: 10.1371/journal.pone.0048175.
Arya Sobhakumari, Brandon M Schickling, Laurie Love-Homan, Ayanna Raeburn, Elise V M Fletcher, Adam J Case, Frederick E Domann, Francis J Miller Jr, Andrean L Simons, NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells,Toxicol Appl Pharmacol 2013 Nov 1; 272(3):736-45, doi: 10.1016/j.taap.2013.07.013.
Elise V M Fletcher, Laurie Love-Homan, Arya Sobhakumari, Charlotte R Feddersen, Adam T Koch, Apollina Goel, Andrean L Simons, EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC, Mol Cancer Res, 2013 Dec;11(12):1574-84, doi: 10.1158/1541-7786.MCR-13-