Arya Sobhakumari
I joined the Human Toxicology Program at the University of Iowa in 2008. Toxicology was one of my favorite subjects while I was studying Veterinary Medicine in India and I wanted to pursue my higher studies in this field. I realized that the Interdisciplinary Program in Toxicology offered by University of Iowa could help me go further in this field.
Thesis Title: NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells
Advisor: Andrean L. Simons-Burnett, PhD
Year of Graduation: 2013
Program: Ph.D.
Current Position: Toxicologist
Current Employer/Institution: Nestle Purina
Publications from Human Toxicology Program Research:
Kevin P Orcutt, Arlene D Parsons, Zita A Sibenaller, Peter M Scarbrough, Yueming Zhu, Arya Sobhakumari, Werner W Wilke, Amanda L Kalen, Prabhat Goswami, Francis J Miller Jr, Douglas R Spitz, Andrean L Simons, Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4, Cancer Res, 2011 Jun 1;71(11): 3932-40, doi:10.1158/0008-5472.CAN-10-3425.
Arya Sobhakumari, Laurie Love-Homan, Elise V M Fletcher, Sean M Martin, Arlene D Parsons, Douglas R Spitz, C Michael Knudson, Andrean L Simons, Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism, PLoS One, 2012;7(10):e48175,doi: 10.1371/journal.pone.0048175.
Arya Sobhakumari, Brandon M Schickling, Laurie Love-Homan, Ayanna Raeburn, Elise V M Fletcher, Adam J Case, Frederick E Domann, Francis J Miller Jr, Andrean L Simons, NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells,Toxicol Appl Pharmacol 2013 Nov 1; 272(3):736-45, doi: 10.1016/j.taap.2013.07.013.
Elise V M Fletcher, Laurie Love-Homan, Arya Sobhakumari, Charlotte R Feddersen, Adam T Koch, Apollina Goel, Andrean L Simons, EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC, Mol Cancer Res, 2013 Dec;11(12):1574-84, doi: 10.1158/1541-7786.MCR-13-
Arya Sobhakumari, Kevin P Orcutt, Laurie Love-Homan, Christopher E Kowalski, Arlene D Parsons, C Michael Knudson, Andrean L Simons, 2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells, Oncol Res, 2016;24(1):55-64, doi: 10.3727/096504016X14586627440192.
