I became interested in toxicology during my undergraduate study, where I learned of adverse effects pesticides have on human health. My interest to study toxicology was further increased when I worked on a project on developmental effect of chlorpyrphos on mice. The interdisciplinary nature of the program offered great opportunities for choice.

Dissertation Title: Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats

Advisor: Hans-Joachim Lehmler, Ph.D.

Program: Ph.D.

Current Position: Postdoctoral Researcher

Current Employer/Institution: University of Arizona

Publications: 

Dhakal, K., Uwimana, E., Adamcakova-Dodd, A., Thorne, P.S., Lehmler, H., Robertson, L.W. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chemical Research in Toxicology 27, 1411-20 (2014)

Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler HJ., Atropselective Oxidation of 2,2',3,3',4,6'-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity, Toxicol Sci. 2019 Jul 3;171(2):406-20

Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ., Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat, Toxicology. 2015 Dec 2;338:59-68

Uwimana E, Li X, Lehmler HJ., 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes, Chem Res Toxicol. 2016 Dec 19;29(12):2108-2110

Uwimana E, Maiers A, Li X, Lehmler HJ., Microsomal Metabolism of Prochiral Polychlorinated Biphenyls Results in the Enantioselective Formation of Chiral Metabolites, Environ Sci Technol. 2017 Feb 7;51(3):1820-1829

Uwimana E, Ruiz P, Li X, Lehmler HJ., Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites, Environ Sci Technol. 2019 Feb 19;53(4):2114-2123

Uwimana E, Li X, Lehmler HJ., Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite, Environ Sci Technol. 2018 May 15;52(10):6000-6008