I joined the Human Toxicology Program at the University of Iowa in 2005.
Toxicology became my field of choice because of its application in various fields. Because toxicology requires knowledge and familiarity of multiple disciplines, I felt that graduate school was necessary to add to my background in biological sciences. The Human Toxicology program not only provides such an opportunity for me to interact and learn from experts within the field of toxicology itself, but also experts from various disciplines relevant to toxicology.
I am currently working on part of Superfund Project 1, determining the effects that certain polychlorinated biphenyls (PCBs) can have on the expression and activity of xenobiotic-metabolizing and antioxidant enzymes in the rat liver, specifically cytochrome P450 (CYP) and glutathione peroxidase (GPx). I also plan to investigate the effects that PCB126, a potent PCB congener, has on the expression and activity of those enzymes in the extrahepatic organs of rats.
Using Dietary Strategies to Explore Mechanisms of Hepatic Toxicity Caused by 3,3',4,4',5 Pentachlorobiphenyl (PCB 126) in an Animal Model
Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. 2009. Acute toxicity of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) in male Sprague–Dawley rats: Effects on hepatic oxidative stress, glutathione and metals status. Environment International (Article in Press)
Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci. 2011 Nov;124(1):202-14. Epub 2011 Aug 24. PubMedCentral PMCID: PMC3196656.
Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology. 2012 Dec 8;302(1):25-33. Epub 2012 Jul 21. PubMed Central PMCID: PMC3438370.
Shen H, Li M, Wang B, Lai IK, Robertson LW, Ludewig G. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Environ Sci Pollut Res Int. 2013 May 4. [Epub ahead of print] PubMed PMID: 23644946.
2008 Society of Toxicology Annual Meeting Graduate Student Travel Award
Abstract Title: THE LOW DOSE EFFECTS OF PCB126 ON RAT LIVER METABOLISM IN RATS GIVEN A CONTROLLED DIETARY LEVEL OF SELENIUM